Saint Thomas Health > Heart > Research and Clinical Trials

Research and Clinical Trials

Enrolling Studies

For more information and to refer a patient for consideration into a Saint Thomas Heart clinical trial, please call our research department at 615.222.4950.

Cardiac Intervention

Trial Name
Lead Physician
Coordinator
ASAP TOO Dr. Robert Pickett-STWest/STMidtown Lisa Evans, RN  
The primary objective of this study is to establish the safety and effectiveness of the WATCHMAN Left Atrial Appendage Closure (LAAC) Device, including the post-implant medication regimen, for subjects with non-valvular atrial fibrillation who are deemed not to be eligible for anti-coagulation therapy to reduce the risk of stroke. The device is intended to reduce the risk of thromboembolic ischemic stroke and systemic embolism.
Amulet Dr. Andrew Morse-STWest/STMidtown Lisa Evans, RN
The objective of this trial is to evaluate the safety and effectiveness of the Amulet device by demonstrating its performance is non-inferior to the commercially available Boston Scientific LAA closure (LAAC) device (Control) in subjects with non-valvular atrial fibrillation.
Ranolazin Dr. Doug Pearce–STWest Shannon Pugh, RN
An Investigator Initiated study to evaluate the effect of Ranolazine on changes in speckle-tracking-derived myocardial strain in patients with areas of non-revascularizable myocardium and evaluate the safety of Ranolazine in patients with ischemic myocardium that is not amenable to revascularization, LV filling patterns, and biomarkers of myocardial ischemia.
Readmission Dr. Dante Graves-STWest Reiner Venegas
A simple program of pharmacogenetic testing for patients at St Thomas Hospital who are hospitalized for acute coronary syndrome (or who are within 30 days of such event), and who are either already on Clopidogrel or who are being initiated on Clopidogrel. The study will evaluate hospital readmission rates at 30, 60, and/or 180 days


Electrophysiology

Trial Name
Lead Physician
Coordinator
Enable MRI Dr. Robert Pickett-STWest/STMidtown Hollie Horton, LPN
The objective of this study is to collect data to confirm the safety and effectiveness of the ImageReady™ MR Conditional Defibrillation System when used in the 1.5T MRI environment under the labeled Conditions of Use.
PSR  Dr. James Baker-STWest/STMidtown Leslie Embry, RN
A Medtronic Product Surveillance Registry whose purpose is to provide continuing evaluation and periodic reporting of safety and effectiveness of market-released products for their intended use. The objective of the PSR platform is to serve as an ongoing source of acute and chronic product performance, patient safety and clinical outcomes information associated with the use of market-released products.


Cardiac Surgery

Trial Name
Lead Physician
Coordinator
Coapt Dr. Evilio Rodriguez-STWest  Judy McCarthy, RN 
A trial to evaluate the safety and effectiveness of the MitraClip System for the treatment of moderate-to-severe or severe functional mitral regurgitation (FMR) in symptomatic heart failure subjects who are treated per standard of care and who have been determined by the site’s local heart team as not appropriate for mitral valve surgery.
Grifols Dr. Chand Ramaiah-STWest Cissie Gregory, RN
A study to evaluate the Safety and Efficacy of Preoperative Antithrombin Supplementation in Patients Undergoing High-Risk Cardiac Surgery with Cardiopulmonary Bypass.
Momentum3 CAP Dr. Don Chomsky-STWest Jan Orga, RN
The objective of the study is to continue to evaluate safety and clinical performance of the HM3 LVAS for the treatment of advanced, refractory, left ventricular heart failure following completion of enrollment in the the MOMENTUM 3 IDE Study.
Partner 3 (Cardiac Surgery) Dr. Evilio Rodriguez-STWest Judy McCarthy, RN
The purpose of this trial is to establish the safety and effectiveness of the Edwards SAPIEN 3 (Edwards Lifesciences, Irvine, California) Transcatheter Heart Valve (THV) in patients with severe, calcific aortic stenosis who are at low operative risk for standard aortic valve replacement (AVR).